How much weight did Oprah Winfrey lose on Ozempic? This side-by-side photo says it all

At 72 years old, Oprah Winfrey’s legendary show business career has often revolved around an unfair topic: her weight. She once said the people It has historically been “blamed and shamed” for its fluctuating size. (Per the star, 211 pounds is the lower end of her body’s “genetically influenced weight range,” or her “enough point.”) But today, her frame is on a positive note as she debuts a new book, Enough, and a new book. A significant shift in weight loss in late life With the help of GLP-1 drug.

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A recent side-by-side photo of Winfrey in 2022 versus 2026 highlights how much she’s slimmed down since she started taking GLP-1s in 2023. According to a 2025 interview with Jane Pauley for CBS NewsShe reduced her weight to about 155 pounds. However, her journey to overcome obesity in her later years reveals several key facts about how GLP-1 works.

The first is that GLP-1 could be safe for adults in their 70s, like Winfrey. (Many celebrities over the age of 50 have used GLP-1 devices.) According to geriatrician Dr. Chitra Ghanta in an article by L American Academy of Medical Colleges (AAMC), is cautious when prescribing GLP-1s to patients over 65 years of age.

However, Dr. Ghanta feels that since a large percentage of older adults are obese, having the opportunity to try GLP-1s could improve their health. In the same AAMC article, Dr. John Patsis admitted that he was not a fan of giving GLP-1 to older patients but tempered his views to a low-dosing philosophy based on current evidence that the drugs may offer help: “Start low, then slow down.”

In fact, “low and slow” is the same advice that “Enough” author Dr. Anya Jastreboff shared with Winfrey during her visit to the center. Show of the day With the star. “If you feel nauseous, do not increase the dose,” she said.

In fact, Winfrey felt big Side effects of GLP-1sBut it wasn’t nausea. Instead, she experienced constipation, another common reported effect of GLP-1. On a daily basis, Winfrey explained that she drinks a gallon of water and takes magnesium to keep her bowels moving.

Winfrey has made another important discovery about GLP-1s since she started working with them three years ago: They don’t protect you from weight gain. While a guest on the podcast”Wild Card with Rachel MartinWinfrey noted: “Well, when I turned 70, I decided, OK, I’ve reached the weight. “I think I can maintain this weight if I continue to eat less, eat all my meals by 4 a.m., keep walking long distances, and keep doing all the things.” Winfrey stopped using GLP-1 and gradually regained 20 pounds. At that point, she decided to go back and continue on medication as a way to maintain her new shape and lifestyle.