5 Celebrities Who Attacked Ozempic and Other GLP-1s

Everywhere you look, it seems there are more and more celebrities jumping on the bandwagon Ozimbek And various other weight loss medications. From Oprah Winfrey to Serena Williams to Rebel Wilson, it seems Hollywood celebrities are dipping their toes into the pharmaceutical weight loss fountain. “The fact that there is a medically approved prescription for weight control and better health, in my life, feels like a relief, like a redemption, like a gift, not something to hide behind and be ridiculed again,” Winfrey said. “I’m completely done with the shame of others and especially myself.” the people in December 2023 about her own experience taking GLP-1.

Unfortunately, for many pro-weight-loss drug celebrities, there seems to be an equal number of weight-loss drug haters — and they’re not afraid to say it. A number of celebrities have publicly discussed their less-than-stellar impressions of Ozempic and other GLP-1s—and sometimes even their first-hand experience with them.

In November 2023, Sharon Osbourne opened up about her struggles after starting Ozempic in December 2022 and continuing it for so long. “I know I look scrawny and I know everything that goes along with that. And I did,” she admitted during an exclusive interview with. Daily Mail. According to Sharon, she lost 42 pounds before eventually deciding to stop taking the medication. “I’m under 100 pounds and I don’t want to be,” she revealed. “You can lose a lot of weight and it’s easy to become addicted to it, which is very dangerous,” she explained.

Meanwhile, it seems her late husband, Ozzy Osbourne, wasn’t a fan of her drug use either. “He doesn’t like it,” she admitted during a November 2023 appearance on the show.Good morning, BritainShe added: “He’s afraid something will happen to me. He says: ‘I’ve gotten thin, then something else will happen.'” “He’s always thinking about the downside – that it’s too good to be true,” she recalled. However, Sharon was very adamant that teenagers should not try weight-loss drugs. She warned on the British breakfast TV show: “I just think it should be in the hands of older people who fully understand that there may be side effects to it.”

Chelsea Handler is definitely anti-Ozembek. But that doesn’t mean she hasn’t unknowingly tried the drug in the past. In January 2023, during an appearance on Alex Cooper’s show “Call her fatherpodcast, Handler revealed that she unknowingly tried the drug. “So, the anti-aging doctor just gave it to anyone,” Handler addressed Cooper (via the people). “I didn’t even know I was exercising. She said, ‘If you want to lose five pounds, that’s good,'” she recalled. It wasn’t until after speaking with another friend who was openly taking the drug, that Handler connected the dots. “This is Ozimbek!” The girlfriend yelled at Handler after Handler shared that she was taking semaglutide.

However, it should be noted that Handler is no longer taking medication. “This is very irresponsible. I’m an irresponsible drug user, but I won’t take my diabetes medication,” she joked. How does the use of Ozempic for weight loss affect diabetics. “I’ve tried that, and I’m not going to do that. This isn’t for me. This isn’t for me,” she concluded.

Kate Winslet didn’t mince any words while discussing Ozempic during an interview with New York Times in March 2024. While Winslet was quick to admit that she wasn’t quite sure what the drug was, once the interviewer explained it to her, she exclaimed: “Oh my God. This sounds terrible. Let’s eat more stuff!” As she dramatically popped another bite of pastry into her mouth.

But later, in 2025, Winslet’s ideas about weight loss drugs became clearer. “Do they know what they’re getting into?” I wondered out loud during a candid interview with The times About other celebrities who take weight loss medications. “Ignoring one’s health is terrifying. It bothers me now more than ever. It’s a hot mess out there.”

Sadly, Winslet is no stranger to thinness pressures. In fact, she admitted to the New York Times that she had an eating disorder. “I never told anyone that,” she said. “Because guess what – people in the world around you are saying, ‘Hey, you look great! I lost some weight!”

jelly roll wife, Bunnie Xo wants everyone to know about her horrific experience with GLP-1s. According to the podcast host and YouTuber, she tried an unnamed weight-loss drug in December 2025, and it backfired miserably, leading to debilitating depression and even suicidal ideation. “It was one of the darkest times in my life and it was scary,” she admitted during a frank interview with the magazine. the people In February. “I’m fine now,” she confirmed, before confirming: “December was a tough month, let me tell you.”

As part of the interview, Bunnie Xo revealed that she chose to try GLP-1 because of her genetic predisposition to diabetes. “My parents had diabetes. So my insulin levels are so crazy my body can’t handle it,” she said. Unfortunately, her body can’t seem to tolerate GLP1 either. “I wish I could be part of this cool crowd and be skinny and weird and not have a care in the world,” she lamented.

Now, Bunnie Xo has made it her mission to let others know about her own experience — scary side effects and all — while also speaking directly to those who have dealt with suicidal thoughts. “I just want people to know that you are not alone. Everyone goes through ups and downs and you deserve to stay here. Please stay… Don’t make a permanent decision based on temporary feelings because they will go away,” she declared.

If you or someone you know is struggling or in crisis, help is available. Call or text 988 or chat 988lifeline.org

Award-winning singer-songwriter Luke Combs has always been very open and direct about his own issues with his weight over the years. “I’ve always struggled with my weight,” he admitted during an interview with The New York Times.popcastPodcast in February 2026. “It bothers me so much that I can’t figure it out. I don’t want my life to be a life full of ease and simplicity, everything is easy. “I like when things are tough.”

However, it seems that Combs’ dissatisfaction with his weight was not enough to make him start trying weight-loss drugs. “As stupid as it sounds, these things scare me more than I think I would enjoy their benefits,” he revealed. As for Combs, he’s determined to do it the old-fashioned way with a little extra effort. “I need to win, and I need to beat myself,” he joked. However, Combs was keen to point out that there is nothing wrong with someone choosing a weight loss drug. “This is personal to you,” he said.